How to make sure you get what you paid for – Symphony Natural Health


Melatonin is available in four different delivery methods: regular-release, immediate-release, time-release and plant.

Regular release melatonin produces an initial spike of the hormone in your bloodstream, often much higher than normally present in your body, even when using a lower dose melatonin. Sublingual melatonin can be absorbed even faster through the mucus membrane, having an immediate effect and can, therefore, result in a higher percentage of the melatonin to be utilized as less of it is metabolized in the liver. However, like regular melatonin, immediate-release causes an initial melatonin spike and drop, which can result in waking up in the night when melatonin levels drop. Time-release, delayed-release or sustained-release allows melatonin to enter your bloodstream more gradually and throughout the night.

Similarly, plant melatonin is gradually released over time as the melatonin is within the cell of the plant, so our natural digestion of the plant means that the melatonin is gradually released over time, mimicking the body’s own melatonin production throughout the night.


Are you getting what you paid for?

Label Claim:

A 2017 study cited by the National Institute of Health (NIH), that tested 31 different melatonin supplements bought from grocery stores and pharmacies, found that the majority (71%) were outside 10% of the amounts claimed on the labels. The worst examples finding that some melatonin supplements had five times the amount listed on the label while others only had 17% of the melatonin listed on the label. Even more concerning, it was revealed that melatonin levels between lots of the same product from the same brand varied by as much as 465%.

In addition, 26% of the supplements contained serotonin, a hormone that can have harmful effects, even at relatively low levels. This is most likely because during manufacturing the synthetically produced melatonin missed a critical step in the synthesis as the core of the two hormones are the same.


Oral melatonin tablets often show poor bioavailability either due to poor oral absorption, poor intestinal absorption, or variability in metabolism through the liver. In addition, many companies use binders or fillers in their capsules or tablets. While these binders and fillers (such as magnesium stearate) improve manufacturing speed and cut down on manufacturing costs, they are unnecessary excipients that may alter absorption.  

Research into the bioavailability of melatonin supplementation has shown that there is huge range of absorption from 1% to 74%. (1,2,3,4,5,6,7)

The bioavailability of melatonin varies depending on several factors, with research into oral and intravenous melatonin showing that only 3% to 33% gets absorbed through the average gastrointestinal tract into the circulating blood stream. The rest is processed by the body through the liver and excreted in the urine. (1,2,3,8)

Interestingly, even though low levels of oral melatonin are bioavailable, what is available is rapidly absorbed with peak levels 20 to 30 min after oral ingestion from standard melatonin and, in some cases, even faster from sublingual. This, combined with a very short elimination half-life of only 40 to 60 minutes, means that, like above, there is often a spike and significant drop in melatonin, resulting in people falling asleep and then waking in the middle of the night.

Studies have also shown that younger subjects and children have higher rates of melatonin elimination (with a much shorter half-life), suggesting age is the biggest factor in melatonin absorption. Interestingly, there has been no difference observed in rates of melatonin metabolism between genders, nor was there a difference between perimenopausal and postmenopausal women with regards to melatonin metabolism.(1,2,3)  


Much of the research around melatonin has shown that light, temperature, and even time do not significantly break down melatonin however, air has been shown to significantly breakdown the efficacy of melatonin, indicating that oxygen-barrier-blister packs could be a key factor in packaging melatonin supplements.

Consumer Lab – a 3rd party consumer watch dog – anonymously reviews various supplements every year. In 2020, they reviewed melatonin supplements from across the country, looking at some of the leading melatonin brands in order to verify which products contained 100% of their label claim, complied with California’s Prop 65 heavy metals limits, and is in compliance with FDA labeling requirements. Herbatonin has been part of that review for over 10 years, and every single time it has not only passed, but is now one of Consumer Lab’s TOP PICKS.


As we do more research on melatonin, it has become clear that the amount of melatonin your body produces itself, combined with the specific health reason for which you are using it, dictates exactly what the ideal dose is for you. The correct dose is so important that research has shown that taking too much for your body can actually result in your circadian rhythm getting thrown out of balance and may cause sleep issues. So, working with your healthcare practitioner is key in establishing the right dose for you personally.

Research on what is the optimal dose or dose range based on each health condition is an entire blog in and of itself and so we’ve done that. To read more on dosing and each health condition please click here.

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